To know if the series converges, we use the comparison test. Let
$L_k:=\lcm(1,2,...,k)$, for $k=1,2,3,...$. By definition, $L_1:=1$ and
note that for $k\geq 2$, $0< L_k\leq k(k-1)$. That is, for each
integer $N>0$,
$$\sum_{k=1}^{N}\frac{1}{L_k}\leq
1+\sum_{k=2}^{N}\frac{1}{k(k-1)}\leq
1+\sum_{k=2}^{\infty}\frac{1}{k(k-1)}=1+\sum_{k=2}^{\infty}\left(\frac{1}{k-1}-\frac{1}{k}\right)=2.$$
This means that $S=\sum_{k=1}^{\infty}\frac{1}{L_k}$
exists and is a positive real number between 1 and 2. To prove that this
number is irrational, we argue by contradiction. Suppose on the contrary
that $S$ is rational, and it can be written as
$$S=\frac{a}{b},$$
where $(a,b)\in\Z\times\Z\backslash\{0\}$, and $a, b$ are coprimes.
Let $p_1,p_2,p_3,...,p_r,...$ be the increasing sequence of prime numbers
greater than $b$. Using the famous Bertrand's Postulate, we know that
$$p_r < p_{r+1}< 2p_r\quad\Rightarrow\quad
p_{r+1}-p_r< p_r,\;\forall r=1,2,3,...$$
Change this to a non-strict inequality, we have
$$p_{r+1}-p_r\leq p_r-1$$
for each $r\in\Z^+$. We will now show that $p_{r+1}-p_r$ is indeed
strictly less than $p_r-1$. To do this, we need to recall a useful lemma
that we will not prove formally:
Lemma 1: There are infinitely primes of the form $3k+2$.
Lemma (1) simply states that for infinitely many primes $p_r$, it holds
that $p_r\equiv 2\;(\modular 3)$. Now, note that if $p_{r+1}-p_r=p_r-1$,
then $p_{r+1}-2\equiv 1\;(\modular 3)$, which means that $p_{r+1}\equiv
0\;(\modular 3)$, and is indeed true for $3$, but not true for infinitely
many primes $p_r$. Hence, $p_{r+1}-p_r< p_r-1$ for infinitely
many $r$. Now, notice that
$$ \begin{align*}
S-S_{p_1-1}&=\left(\sum_{k=1}^{\infty}\frac{1}{L_k}-\sum_{k=1}^{p_1-1}\frac{1}{L_k}\right)=\sum_{k=p_1}^{\infty}\frac{1}{L_k}=\frac{1}{L_{p_1}}+\frac{1}{L_{p_1+1}}+\frac{1}{L_{p_1+2}}+\cdots\\
&=\left(\frac{1}{L_{p_1}}+\frac{1}{L_{p_1+1}}+\cdots+\frac{1}{L_{p_2-1}}\right)+\left(\frac{1}{L_{p_2}}+\frac{1}{L_{p_2+1}}+\cdots+\frac{1}{L_{p_3-1}}\right)+\cdots\\
&=\sum_{r=1}^{\infty}\sum_{k=p_r}^{p_{r+1}-1}\frac{1}{L_k}=\frac{1}{L_{p_1-1}}\sum_{r=1}^{\infty}\sum_{k=p_r}^{p_{r+1}-1}\frac{L_{p_1-1}}{L_k}.
\end{align*} $$
Notice also that $L_{p_1-1}=\lcm(1,2,...,p_1-1)$ is a multiple
of all primes less than $p_1$, and $L_k=\lcm(1,2,...,k)=\lcm(1,...,p_r)$
is a multiple of all primes less than $p_r$. Therefore
\begin{align*} 0 < S-S_{p_1-1}&\leq
\frac{1}{L_{p_1-1}}\sum_{r=1}^{\infty}\sum_{k=p_r}^{p_{r+1}-1}\frac{2\cdot
3\cdot 5\cdots (p_1-1)}{2\cdot 3\cdot 5\cdots
(p_1-1)p_1\cdots p_r}\\
&=\frac{1}{L_{p_1-1}}\sum_{r=1}^{\infty}\sum_{k=p_r}^{p_{r+1}-1}\frac{1}{p_1p_2...p_r}=\frac{1}{L_{p_1-1}}\sum_{r=1}^{\infty}\frac{1}{p_1p_2\cdots
p_r}\sum_{k=p_r}^{p_{r+1}-1}1\\
&=\frac{1}{L_{p_1-1}}\sum_{r=1}^{\infty}\frac{p_{r+1}-p_r}{p_1p_2\cdots
p_r}<
\frac{1}{L_{p_1-1}}\sum_{r=1}^{\infty}\frac{p_r-1}{p_1p_2\cdots
p_r}\\
&=\frac{1}{L_{p_1-1}}\sum_{r=1}^{\infty}\left(\frac{1}{p_1\;...\;p_{r-1}}-\frac{1}{p_1...p_r}\right)\\
&=\frac{1}{L_{p_1-1}}\left(1-\frac{1}{p_1}+\frac{1}{p_1}-\frac{1}{p_1p_2}+\frac{1}{p_1p_2}-\frac{1}{p_1p_2p_3}+\cdots\right)\\
&=\frac{1}{L_{p_1-1}},
\end{align*}
which is the same as saying that
$$ \begin{equation*}\label{eqn: lcm_1} 0<
SL_{p_1-1}-S_{p_1-1}L_{p_1-1}< 1.
\end{equation*} $$
Recall that we defined $p_1$ to be a prime number greater than $b$, therefore,
$b\in\{1,2,...,p_1-1\}$, and hence $L_{p_1-1}=\lcm(1,2,...,p_1-1)$
must be a multiple of $b$; i.e., $L_{p_1-1}=kb$ for some integer
$k$. This means that
$$SL_{p_1-1}=\frac{a}{b}\cdot
kb=a\cdot k\in\N.$$
Let us remind ourselves of the formula of $\lcm$ for a list of numbers.
Lemma 2: For an integer $m\geq k$, we have
$$L_m=\lcm(1,2,...,m)=\lcm(\lcm(1,2,...,k),k+1,...,m).$$
Ok, but why? This lemma is left as an exercise for the reader.
The lemma says that $L_m$ is a number divisible by $\lcm(1,2,...,k)$,
and hence $\lcm(1,...,m)=h\lcm(1,...,k)$, for some $h\in\Z$.
Therefore, for the term $S_{p_1-1}L_{p_1-1}$,
$$S_{p_1-1}L_{p_1-1}=\sum_{k=1}^{p_1-1}\frac{L_{p_1-1}}{L_k}=\sum_{k=1}^{p_1-1}\frac{\lcm(1,2,...,p_1-1)}{\lcm(1,2,...,k)}\in\N,\;1\leq
k\leq p_1-1.$$
This means that
$$SL_{p_1-1}-S_{p_1-1}L_{p_1-1}\in\N,$$
which is completely nonsensical, since this implies that there is an integer
somewhere between $0$ and $1$. Therefore, the original statement must be
true and $S$ is irrational.